Metastatic squamous lung cancer can be treated by chemotherapy, radiotherapy, targeted therapy, immunotherapy and surgery. 1. Chemotherapy: pemetrexed, vincristine, paclitaxel, docetaxel, cisplatin and other drugs are commonly used after metastasis of squamous lung cancer. 2. Radiotherapy: it is suitable for brain metastasis or isolated metastasis of squamous lung cancer. It uses radioactive irradiation to release energy from the tumor to kill cancer cells. 3. Targeted therapy: after metastasis of squamous lung cancer, patients with specific gene mutation can use targeted drugs such as gefitinib to inhibit tumor growth. However, fewer patients with squamous lung cancer have these gene mutations. However, patients with squamous lung cancer can use targeted drugs such as bevacizumab, which target the proliferation of neovascularization of the tumor, to control the growth of the tumor by inhibiting the angiogenesis of the tumor. 4. Immunotherapy: If PD1 (programmed cell death receptor 1) or PD-L1 (programmed death receptor-ligand 1) is highly expressed in the tumor after metastasis of squamous lung cancer, immune checkpoint inhibitors such as cindolizumab and tirilizumab can be applied to activate the body’s immune system to kill tumor cells. 5. Surgery: Radical surgery can be performed if the metastasis of squamous lung cancer is limited. If the metastasis has been widely spread, palliative surgery can be performed to alleviate the symptoms and improve the quality of life of the patients, as the invasion of individual tumors has a great impact on their quality of life. After metastasis of squamous lung cancer, it can be treated in the above ways, especially the combined treatment of multiple treatment modalities can prolong the life of patients and reduce their pain.