No studies have shown that statin causes elevated homocysteine. Elevated homocysteine, however, is an important risk factor for ischemic cerebrovascular disease, and its elevation is generally associated with nutritional deficiencies, genetics, medications and diseases, and high-fat diets. No studies have shown that statin causes elevated homocysteine. Statins are commonly used lipid-lowering drugs in clinical practice today, like Rosuvastatin and Simvastatin. The most important adverse effects of statins are impairment of liver function and rhabdomyolysis, with some patients experiencing elevated aminotransferases, muscle pain or weakness. They are contraindicated in patients with active liver disease or unexplained persistent elevation of aminotransferases, in pregnancy, and in people who are allergic to statin components. It is recommended to choose and take statin drugs under the guidance of a doctor, and regularly review liver function, and immediately consult a doctor if there is any discomfort during the course of taking the drug.