Many diabetic patients report gradually becoming thinner, and the patients’ own feelings are that their legs are getting thinner. Some patients will use this as a sign of worsening disease and are often depressed by it. The fundamental problem that causes these conditions in diabetic patients is high blood sugar. High blood glucose is too much glucose in the blood, and high blood glucose causes the patient to develop a hyperosmolar state, a state that leads to the abnormalization of the functions of many organs in the body, such as the failure of the kidneys. The gradual thinning of the legs of diabetic patients is also the cause of high blood sugar. When the blood sugar in the body is too high, polyuria occurs, and the urine excreted takes away glucose from the body. Glucose is the main form of energy in the body and is the main driving force for the functioning of the organism. Once the body is deficient in this glucose, the body will convert other substances into this energy on its own to keep the body functioning properly. This vicious circle occurs in the body of diabetic patients due to excessive sugar in the blood leading to polyuria, which in turn leads to a large loss of glucose in the body, and then the body converts other energy into glucose to balance the normal functioning of the body, but the end result is that the body is always in a state of nutrient loss. The main reason why diabetics’ legs tend to get thinner is the result of the transformation of substances in this vicious circle. When the sugar in the body flows out of the body, the body will transform other substances, and protein is the main substance to be transformed. Protein is the main component of muscle, and the legs are the most muscular part of the body, so that, from the outside, the patient’s legs gradually become thinner. In fact, the appearance of such a problem in the organism is a sign that the condition of the diabetic patient has reached a certain level.