This is due to the fact that pancreatic beta cells are hit in both the over-starved and over-fed states, leading to hypofunction and relative or absolute insufficiency of insulin secretion. Type 2 diabetes is a disease of metabolic disorder caused by insufficient or impaired insulin secretion in the body. In obese people, the body’s ability to utilize insulin is reduced and insulin resistance is produced. In the early stage, in order to overcome insulin resistance, the pancreas will synthesize a large amount of insulin, resulting in the blood insulin level of obese people is much higher than that of ordinary people, which is the so-called “hyperinsulinemia”. Afterwards, due to the excessive work of the pancreatic beta cells, the function of the pancreas to synthesize insulin gradually fails, and the insulin production is gradually insufficient to lower the blood sugar to the normal range, and then diabetes appears. Therefore, obese people are a high-risk group for diabetes. Clinical observation found that this group of people who experienced famine in the 1960s and improved life and excessive diet after reform and opening up had a high rate of diabetes, which is related to this mechanism of action. Obese people should lose weight in time Obese people, whether they have diabetes or not, should lose weight in time through a balanced diet and active exercise. Diabetes has occurred, but also in accordance with medical advice with the use of hypoglycemic drugs. Of course, the weight should not be reduced too low. Some young women are now overweight, too much weight loss leads to endocrine disorders, and even infertility, premature aging, which is also detrimental to health. Obese people in the process of weight loss should also pay attention to the method to avoid misconceptions. Professor Lu said that weight loss is not the same as not eating sugar, not eating staples, living an ascetic life. A scientific and reasonable diet is most important. Should be under the premise of total energy control, pay attention to reasonable distribution, balanced nutrition. How can we calculate the total energy intake per day? First, calculate the ideal body weight, the simple algorithm is height (cm) – 100 for men and height (cm) – 105 for women. then calculate the total caloric intake based on activity level. The daily caloric intake for adults is estimated as: basal calories (22 kcal/kg x ideal body weight) + calories required for activity. In general, for the resting state, the caloric intake for adults is 10% increase in basal calories; for moderate activity, 20% increase in basal calories; and for high activity, 40% increase in basal calories. In addition to controlling the total energy intake without exceeding the limit, we should also pay attention to a reasonable dietary structure. In general, the calories provided by sugar (i.e. ordinary rice or pasta) should account for 55%-60% of the total calories. Fat accounts for 20-25%, and protein accounts for 10-20%. Through a reasonable dietary structure, together with active exercise and healthy lifestyle improvement, blood sugar will quietly benefit in the process of bringing weight control up to standard.