Colds, i.e. upper respiratory tract infections, antigen rapid test currently refers to the new coronavirus antigen rapid test, which will not show a positive result with antigen rapid test. The antigen rapid test is used to detect novel coronavirus infections. Upper respiratory tract infections are usually caused by pathogens such as parainfluenza virus and adenovirus infections. Patients with upper respiratory tract infections will not show positive results when using antigen rapid test strips. Antigen Rapid Test is mainly used to detect novel coronavirus. In case of novel coronavirus infection, the result of Antigen Rapid Test will show positive. Patients with upper respiratory tract infections are due to viral infections but caused by parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, echovirus, measles virus, coxsackievirus, and so on. So the patient will not show a positive result when he/she undergoes rapid antigen detection test paper. Patients with upper respiratory tract infections will not show a positive result with antigen rapid test. It is recommended that patients should go to the hospital in time when they have uncomfortable symptoms and follow the doctor’s instructions for examination, and should not diagnose the condition on their own.