Small blisters on the skin of the penis may be caused by genital herpes, pearly penile papulosis, circumcision and glans penis and other diseases. 1. Genital herpes: genital herpes is a sexually transmitted disease caused by herpes simplex virus infection, prevalent in sexually active people, shouting localized blisters, vesicles or ulcers and other symptoms, may be accompanied by itching and other discomfort. 2. pearly penile papulosis: pearly penile papulosis is a disease that occurs in the coronal edge of the penis and the coronal groove, mostly related to local irritation, developmental variations, etc., which will lead to the appearance of localized white and yellow pimples in the form of pearls. 3. Foreskin glans: Foreskin glans is the glans caused by infection, trauma or irritation, the patient will appear locally red, swollen, vesicles and ulcers and other symptoms, and in severe cases, local blisters will also appear. Causes of small blisters on the penile skin are more reasons, it is recommended that patients go to the hospital, relevant examinations, a clear diagnosis.