Two-week-old babies always wake up at night may be caused by physiological factors such as noisy environment, inappropriate temperature and humidity, or may be caused by vitamin D deficiency, indigestion and other diseases. 1. Physiological factors: If the two-year-old baby always wake up at night, consider the indoor environment is too noisy, or the temperature is too low or too high, the air is too dry and other reasons. 2. Vitamin D deficiency: Vitamin D deficiency is a nutrient deficiency disease, mainly caused by the lack of vitamin D in the body, infants and young children with vitamin D deficiency, mostly associated with insufficient sunshine, increased demand, insufficient supplementation through food, etc., the affected children will appear to be increased neural excitability, which will lead to waking up at night, sweating and other symptoms. 3. Indigestion: Indigestion is mainly caused by a combination of genetic, infectious, and environmental factors. If the baby does not eat properly and develops indigestion, it will cause epigastric pain, a feeling of fullness and bloating after meals, which will affect the sleep, and the baby will always wake up at night. There are many reasons why a two-week-old baby always wakes up at night, and it is recommended that the family take the child to the doctor for examination and a clear diagnosis.