Splenomegaly caused by liver cirrhosis is mainly treated by conservative treatment or surgery. 1. Conservative treatment: patients with liver cirrhosis may easily have hypersplenism, which is mainly manifested as splenomegaly and hematocrit, early on, red blood cell and platelet transfusion can be taken according to doctor’s prescription, which can generally relieve the symptoms; granulocyte colony-stimulating factor and erythropoietin can be injected according to doctor’s prescription as well. 2. Surgery: if the splenomegaly of cirrhosis patients is more serious, surgery can be taken when necessary, including minimally invasive surgery and open surgery. Minimally invasive surgery is commonly used in radiofrequency ablation treatment, which has fewer postoperative complications; open surgery is mainly partial splenectomy. Splenomegaly caused by liver cirrhosis should be treated in a timely manner by doctors to avoid aggravation of the condition.