Magnesium sulfate can be orally poisoned, can also be injected overdose poisoning, found poisoning treatment as follows: 1, immediately stop the drug, on the cardiac monitoring, monitoring the patient’s respiration, heartbeat, blood pressure and pulse oxygen saturation, give oxygen, while tying the needle fast infusion. 2, the patient who is not breathing well need to immediately tracheal intubation on the ventilator, the early application of calcium to counteract, can be intravenous push 10% of calcium gluconate or 3, if it is a large number of oral magnesium sulfate poisoning patients, to promptly induce vomiting, gastric lavage, and drink a lot of water. 4, if the patient’s kidney function is normal, but also a large number of infusion of glucose saline, and then intravenous push strong diuretic furosemide to promote magnesium excretion. 5, but also on hemodialysis, but also with peritoneal dialysis, can be faster to clear the blood 6, the other is symptomatic treatment.