Reflux esophagitis take omeprazole does not work may have to do with the treatment program, condition, life diet and other factors. 1. Treatment program: if the effect of a single drug is not good, a combination of drugs can be used. Commonly used drugs are proton pump inhibitors such as omeprazole, rabeprazole, etc., gastrointestinal tract dynamics such as mosapride, domperidone, etc., mucosal protective agents such as colloidal bismuth pectin, teprenone, etc.. 2. Treatment plan: If the effect of internal medicine conservative treatment is not satisfactory, surgical treatment should be considered. Commonly used surgical methods include anti-reflux surgery, gastric fundoplication and so on. 3. Diet: If you don’t pay attention to the diet, the treatment effect may be unsatisfactory. Adjust the diet structure, avoid spicy and stimulating foods; change bad eating habits, such as eating before going to bed, lying down after meals, etc.; moderate exercise can promote gastric emptying and reduce acid reflux. When taking omeprazole for reflux esophagitis does not work, it is recommended to consult a doctor in time to analyze the cause and adjust the treatment.