A high reticulocyte percentage is usually indicative of a strong hematopoietic function of the bone marrow, and is commonly caused by physiological factors, various types of proliferative anemia, and so on. Different causes, different treatment modes, including drug treatment. 1. Physiological factors: such as blood donation, bone marrow hematopoiesis will be more vigorous after blood donation, generally no special treatment is needed. 2. Various proliferative anemia: such as megaloblastic anemia, iron deficiency anemia, etc., due to the increased destruction of peripheral red blood cells, which stimulates bone marrow hematopoiesis. Common treatments include vitamin B₁₂ supplementation, folic acid, iron and so on. However, high reticulocyte percentages can also occur after taking vitamin B₁₂, folic acid, and iron supplements, indicating that the anemia is well-treated and that no extra treatment is usually necessary. In conclusion, when a high reticulocyte ratio occurs, systematic examination is recommended to clarify the cause of the disease and early treatment to avoid delaying the condition, and all medications should be used in accordance with medical advice.