High creatinine may be due to renal insufficiency or a transient elevation due to physiologic reasons. The source of creatinine is mainly from the body’s own muscle catabolism as well as food intake, and it is excreted mainly by the kidneys through urine. Therefore, elevated creatinine is often indicative of renal insufficiency and is more commonly seen in acute kidney injury or various chronic kidney diseases. However, there are some physiological conditions, such as strenuous exercise leading to increased muscle breakdown, or dietary intake of large amounts of meat or creatine and other creatinine-producing substances, can also lead to a transient increase in creatinine. In addition, a transient increase in creatinine can also occur when the body’s catabolism is enhanced by fever, for example. Therefore, elevated creatinine is not necessarily caused by renal insufficiency. If you find that creatinine is elevated, it is recommended to go to regular hospitals for consultation, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of doctors.