Taking loratadine tablets for a long period of time, there is a possibility of developing drug resistance, but also pay attention to the adverse effects of the drug. Loratadine tablets are antihistamine western drugs that can relieve symptoms associated with allergies, such as runny nose, sneezing, nasal congestion, itchy nose, itchy eyes, chronic urticaria, itchy skin disease and allergic skin disease caused by related symptoms. Patients with chronic urticaria can take the medication under the guidance of a doctor, but it should be noted that if the medication is taken for a long period of time, there is a possibility of drug resistance, leading to an increase in the dosage of the medication. Long-term use of loratadine, but also pay attention to the adverse effects of the drug. Such as dry mouth, drowsiness, weakness, headache, nausea, gastritis, rash. Rarely occur hair loss, tachycardia, palpitations, allergic reactions, abnormal liver function. It is recommended that patients read the drug instructions in detail, but also follow the doctor’s instructions to avoid adverse effects.