The risk of lung cancer is higher when neuronal enolase is higher than 16.3ng/mL. When neuron-specific enolase is significantly higher than 16.3ng/mL, it suggests a higher risk of lung cancer, and it is likely to suffer from malignant diseases such as small cell lung cancer and neuroblastoma. In order to confirm the diagnosis, further examination is needed, including pathological tissue biopsy, magnetic resonance, CT and other related examinations combined with clinical symptoms such as chest pain, chest tightness, coughing up blood, dyspnea, and weight loss can confirm the diagnosis. In addition, this indicator alone does not determine the benign or malignant nature of the disease, if the indicator is mildly elevated, it is also considered to be caused by pneumonia or bronchial asthma. People with high neuronal enolase need to actively seek medical attention and follow the doctor’s instructions to use medication, do not self-medication, to avoid adverse consequences.