Due to individual differences, it is not clear how many cycles of chemotherapy are best for mid-stage colon cancer. For colon cancer that meets the indications of chemotherapy, 8 cycles of chemotherapy are usually needed, but individualized chemotherapy regimen needs to be formulated according to the stage of the disease, the patient’s physical condition and the treatment effect. Chemotherapy is a common therapy for cancer patients, through which some cancer cells can be inhibited from spreading. For mid-stage colon cancer patients, about 8 courses of chemotherapy are usually needed to help control the disease and prolong the survival period. However, the exact number of chemotherapy cycles is related to the tumor type, stage and choice of chemotherapy regimen. Even if the chemotherapy regimen is chosen, its chemotherapy course is not fixed, and needs to be adjusted according to the patient’s response to chemotherapy and tolerance level to adverse reactions. Patients with mid-stage colon cancer should go to the hospital for examination in time and be treated under the guidance of doctors.