The causes of itchy foreskin with blisters include repeated friction, pearl rash, prepuce glans and genital herpes. 1. Repeated friction: excessive friction, squeezing and other mechanical or physical stimulation, may cause local skin blisters, such as excessive masturbation may cause local single blisters, blister wall is thin and blister liquid is clear, accompanied by mild pain, stop stimulation blisters can be gradually absorbed. 2. Pearl rash: the foreskin blisters may be penile pearl rash, this blisters single existence, not fused with each other, generally a row or rows, will not cause any discomfort symptoms, and do not need special treatment. 3. Foreskin and glans inflammation: When you don’t pay attention to genital hygiene, the inner plate of the foreskin and the head of the penis bacteria breed, producing an inflammatory reaction, redness, swelling, pain and other discomforts, small blisters can appear on the foreskin, and continue to develop to form erosion or ulcers. The presence of circumcision, circumcision leads to the recurrence of the foreskin glansitis, can be elective circumcision surgery. 4. Genital herpes: a sexually transmitted disease, caused by the herpes simplex virus invading the skin and mucous membranes of the penis, usually after infection, there will be scattered small blisters on the foreskin, penis, perianal area, and then break down to form vesicles or ulcers, combined with pain, chills, fever and other systemic symptoms. Antiviral treatment should be actively carried out, and commonly used drugs include acyclovir and vasiclovir. If physiological factors are excluded, timely medical treatment should be sought, so as to ask the doctor to clarify the cause of the disease, and follow the doctor’s advice to carry out appropriate treatment.