Duodenal nocturnal pain generally refers to the acute attack of duodenal ulcer, the treatment of duodenal ulcer mainly includes medication such as omeprazole, aluminum thioglycollate, elimination of harmful environmental factors and reduction of mental stress. 1. Medications: The main medications for duodenal ulcer are those that reduce the acidity of the stomach, such as the H2 receptor antagonist cimetidine and the proton pump inhibitor omeprazole, etc., and those that enhance the resistance of the gastric mucous membrane, such as aluminum thioglycollate and prostaglandins. 2. Eliminate harmful environmental factors: avoid the use of ulcer-causing drugs such as aspirin, quit smoking and pay attention to dietary habits. 3. Reduce mental stress: Anxiety can increase pain in duodenal ulcer patients, so it is necessary to reduce mental stress in ulcer patients. Specifically, it is necessary to actively seek medical advice and follow the doctor’s instructions for medication.