Patients who have no tears at all may be caused by dry syndrome, dry eye and other diseases, patients can improve their condition through medication, physical therapy, surgery and other ways. 1. Dry eye syndrome: patients can use immunosuppressants, such as cyclophosphamide, azathioprine, etc.; biological agents, such as rituximab, etc. for treatment, and patients can also use artificial tears to alleviate the condition. Patients with more serious symptoms of dry eye can be treated by tear point embolization, lid margin fusion, autologous mucous membrane transplantation and so on. 2. Dry eye: patients can follow the doctor’s instructions to use lachrymatory drugs, such as bromhexine, brucine hydrochloride, neostigmine and so on to promote the secretion of tears, but also can use artificial tears to improve the symptoms of dry eye. For patients whose conservative treatment is not effective or whose symptoms are severe, surgical treatment can be performed through lacrimal punctum closure surgery and autologous submaxillary gland transplantation. It is recommended that patients strictly follow the doctor’s prescription of medication, actively cooperate with the doctor’s treatment, pay attention to eye hygiene in life, avoid eye fatigue, do not use dirty hands or dirty objects to wipe the eyes and so on.