The combination of glutamine and vitamin B1 can treat some of the insomnia. Glutathione is mainly used for the treatment of neurosis, anxiety, menopausal syndrome; Vitamin B1 is used for the treatment and prevention of vitamin B1 deficiency such as neuritis, dyspepsia, beriberi and so on. 1. Glutathione has the effect of regulating the disorders of plant nervous function and endocrine balance; side effects include fatigue rash, breast swelling and pain, hair loss, oil secretion, weight gain, nausea and vomiting, etc.; caution is advised for children, pregnant women, drivers, and peptic ulcers; allergy is prohibited; Glutathione is usually taken for not more than one week. 2. Vitamin B1 has a nutritious nerve and tranquilizing effect; side effects include itching, facial edema, dizziness, headache, fatigue, loss of appetite, etc.; pregnant women, children should be cautious; allergy is prohibited; vitamin B1 should not be combined with alkaline drugs such as sodium bicarbonate. If the patient suffers from insomnia, it is recommended to go to a regular hospital, standardized diagnosis and treatment under the guidance of a professional physician, the use of drugs need to consult a clinical pharmacist and physician.