Swollen vaginal opening may be caused by skin allergy, vulvodynia, vestibular cyst, vaginitis and many other reasons, and should be treated according to the cause. 1. Skin allergy: new underwear, sanitary napkins and so on may cause vulvar skin allergy and redness and swelling of the vaginal opening, at this time, we should avoid contact with allergens, choose suitable underwear, sanitary napkins and so on may improve the symptom, if the allergy is serious, can be used to treat with anti-allergy medication, such as ibuprostin tablets. 2. Vulvovaginitis: women suffering from vulvovaginitis may have redness and swelling of the vaginal opening, warm water sitz bath to promote the dissipation of inflammation, and at the same time the application of anti-inflammatory ointment, such as erythromycin ointment, etc., the serious cases should be added with antibiotics, such as metronidazole, levofloxacin and other treatments. 3. Vestibular cysts: when the opening of the vestibular gland duct is blocked, secretions accumulate in the gland cavity to form vestibular cysts, which will also have the manifestation of swelling of the vaginal orifice, amoxicillin and roxithromycin should be used for treatment, and at the same time, according to the specific circumstances, cystectomy, vestibular cyst stoma or incision and drainage treatment can be used. 4. Vaginitis: women’s body resistance decline, vaginal flora disorders may cause vaginitis, the vaginal opening is stimulated by inflammation will also be red and swollen, should be identified which type of vaginitis, to be different drug treatment. There may be other reasons for the swelling of the vaginal opening, and it is recommended that the patient consult a doctor in time for a clear diagnosis and targeted treatment.