Walker, generic name of volnoxan fumarate tablets, belongs to a new type of proton pump inhibitor, and is indicated for reflux esophagitis. The drug’s mechanism of action is to inhibit gastric acid secretion, in the mechanism can relieve the esophageal mucosal damage caused by gastric acid reflux, so as to alleviate the development of Barrett’s esophagus, the specific efficacy varies from person to person. Barrett’s esophagus refers to the lower end of the esophagus complex squamous epithelium is replaced by a single layer of columnar epithelial cells, often secondary to reflux esophagitis, belongs to the pre-cancerous lesions of esophageal cancer, therefore, generally need to be timely treatment after the discovery of the drug treatment is preferred to the proton pump inhibitor, which can be reversed to a certain degree of Barrett’s esophagus, but also the choice of endoscopic treatment, surgical treatment and other means. And vonorasan fumarate tablets belong to a kind of proton pump inhibitor, so it can be used for the treatment of Barrett’s esophagus. The most common adverse reactions are diarrhea and constipation. It needs to be contraindicated in people who are allergic to the product and those who are receiving atazanavir or rilpivirine, and the prudent use of the population includes the elderly, those who suffer from kidney disease and liver disease. The use of specific drugs should be under the supervision of a specialist.