Taking spironolactone 2 tablets usually works after 24 hours. Spironolactone is a potassium-preserving diuretic, also known as an aldosterone receptor antagonist. After taking it, it acts on the collecting duct and distal tubule, thus antagonizing aldosterone, or directly antagonizing the aldosterone receptor, as well as inhibiting the sodium channel on the luminal membrane of the tubule, thus playing a diuretic role. It is mainly used clinically in the treatment of aldosterone-elevated intractable edema and congestive heart failure. After oral administration, most of it will be rapidly metabolized by the liver to active canrenone, thus exerting its effect. It usually takes about 24 hours for the drug to take effect, and the peak concentration of the drug is reached in 48-72 hours. Nausea, vomiting, stomach cramps and other discomforts may occur after taking the drug. Meanwhile, it is forbidden to use it for patients with hyperkalemia, and should be used with caution for patients with renal insufficiency, hepatic insufficiency, hyponatremia, acidosis and athletes. For pregnant and lactating women, the drug should be used under the guidance of a doctor. If you need to take spironolactone tablets for treatment, it is recommended to consult a doctor in time to decide the dosage of the drug and the matters to be noted after the doctor’s comprehensive assessment of the condition.