Whether blood creatinine 128μmol/L can return to normal is usually determined by the etiologic condition. If the creatinine is elevated due to physiological reasons or acute kidney injury, the creatinine may return to normal after removing the influencing factors. If the creatinine is elevated due to chronic kidney disease, with the progress of the disease, it may develop into uremia, at this time, creatinine usually can not return to normal. Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women. Mild elevation of blood creatinine 128μmol/L may be caused by physiological reasons or by pathological reasons such as acute kidney injury or chronic renal insufficiency. 1. Physiological reasons: part of creatinine elevation may be caused by the patient’s own high muscle content, or eating more meat and exercising more, if there is no abnormality in urine routine and ultrasound of the urinary system and other related examinations, and it is clear that there is no obvious disease of the kidneys, and after improving the life style, the creatinine may gradually return to normal. 2. Pathological causes: If the patient’s creatinine is elevated due to acute kidney injury, the creatinine may return to normal after correcting the reversible causes. If the creatinine is elevated due to chronic kidney disease, the kidney has been irreversibly damaged, and with the progress of the disease, it is possible to develop into uremia, at this time, creatinine usually can not return to normal. If patients find that the blood creatinine is elevated, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.