Blisters on the palate of the mouth can be caused by burn herpes due to eating hotter foods or oral herpes due to oral herpes simplex. It is treated by general measures such as picking, and by using anti-infective drugs. 1. Burning herpes: If the blisters on the palate caused by eating hotter food, they are burning blisters. Smaller blisters caused by scalding are recommended to use a gargle, pay attention to diet, and when they are larger, they are picked, and antibiotics are used when there is a tendency to infection, and the infection is controlled by taking medicines such as cefaclor capsules, azithromycin tablets, and cefixime granules under the direction of a physician. 2. If oral herpes: if the blisters are gathered in clusters, it may be due to oral herpes after infection with herpes virus, and need to take acyclovir dispersible tablets, ribavirin granules, amantadine hydrochloride tablets and other medications under the guidance of a physician for antiviral treatment. When blisters appear on the palate of the mouth and cannot be relieved on their own, they should go to the hospital in time for active treatment, and the medication should be used according to the doctor’s instructions, avoiding self-medication, so as not to delay the condition or cause discomfort.