Exemestane can be taken with methylcobalamin. Exemestane, is generally used for postmenopausal patients with advanced breast cancer whose disease has progressed after tamoxifen treatment. Its adverse reactions are mainly dry mouth, nausea, constipation, diarrhea, insomnia, and skin rash. In addition, exemestane should not be used in combination with other estrogen-containing drugs such as ethinyl estradiol and estradiol, as this will reduce their pharmacologic effects. It should also be prohibited for use in premenopausal women and women during pregnancy, and should be used with caution if the patient has impaired hepatic or renal function. Mecobalamin is an endogenous vitamin B12, which is the main treatment for peripheral neuropathy, and is generally used to treat peripheral neuropathy and megaloblastic anemia caused by vitamin B12 deficiency. Its adverse reactions are mainly headache, rash, feverish sensation and sweating. It should be noted that this product should be contraindicated for those who are allergic to it. When exemestane and methylcobalamin are taken at the same time, there is usually no drug interaction, so they can be taken together. However, whether patients need to take these two drugs at the same time should go to the hospital to be decided by the doctor according to the patient’s condition. Patients should not take these two drugs on their own to avoid serious consequences or delays.