The restlessness of the elderly at night can be caused by mental and psychological factors, but it can also be caused by organic brain diseases. Most of the old people have poor sleep quality, short sleep cycle and reduced deep sleep, and if combined with mental anxiety and nervousness, restlessness and nonsense phenomenon can occur at night. If there is no abnormality in cranial examination, sedative and sleep-aiding drugs can be given in accordance with the doctor’s instructions, such as ghrelin, seven leaves of the God of peace tablets to improve sleep. The old man’s restlessness and nonsense at night can be seen in brain atrophy, vascular dementia or craniocerebral trauma caused by brain function damage and mental disorders. If the elderly recently appeared at night obvious agitation accompanied by cognitive abnormalities, be alert to the possibility of cerebrovascular accidents, need to go to the hospital as soon as possible to the neurology department for further examination to clarify the diagnosis, and then according to the cause of the use of edaravone, hemosiderosis and other drugs to improve brain function, dredge blood vessels treatment. The drugs should be used according to the doctor’s prescription.