Limb twitching after craniotomy is not normal, it may be caused by brain injury resulting in epilepsy and other diseases, which need to be treated in time. Craniotomy is mostly seen in diseases such as intracranial hemorrhage, skull fracture, intracranial tumor, etc. These primary diseases may cause intracranial nerve injury, which causes abnormal discharges of brain tissues leading to epilepsy, which may be manifested as limb twitching and spasms. On the other hand surgery may cause some stimulation to the cerebral cortex, causing secondary epilepsy. When epilepsy symptoms appear, patients are advised to go to the hospital in time. Antiepileptic drugs such as carbamazepine and phenytoin sodium are commonly used clinically for control. However, it should be noted that the medication regimen and dosage of such drugs have great individual variability, and need to be used under the guidance of the clinician, and unauthorized use of drugs is prohibited.