The treatment of testicular microstones is mainly symptomatic, such as the use of acetaminophen, tamoxifen and other drugs. The etiology and pathogenesis of testicular microstones are currently unknown, and there is no complete and unified treatment and prevention program. Its treatment is mainly symptomatic, including the use of acetaminophen and other drugs for anti-inflammatory, pain treatment; most of the conditions will improve, but the symptoms are prone to recurrence. Infertility can be treated with drugs such as tamoxifen, but the effect is not very obvious. It should be noted that testicular microstones follow-up is very necessary, should be followed up once every 6 to 12 months, the purpose is to timely detection of testicular precancerous lesions and tumors. Medications such as acetaminophen and tamoxifen need to be administered under the guidance of a clinician. The presence of testicular microstones suggests prompt medical attention and regular follow-up.