Ibuprofen and acetaminophen, which are among the NSAIDs, have fewer side effects, and both can be used by children to reduce fever. The details are introduced as follows: 1. Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug. Through the inhibition of cyclooxygenase, reduce the synthesis of prostaglandins, produce analgesic, anti-inflammatory effect; through the hypothalamus thermoregulatory center and play a role in antipyretic. Common side effects are gastrointestinal adverse reactions that can occur, including dyspepsia, heartburn, stomach pain, nausea, and vomiting, which usually do not require discontinuation of the drug. Contraindications are allergic to aspirin or other non-steroidal anti-inflammatory drugs, allergic to the product is prohibited; active or a history of previous peptic ulcer, gastrointestinal bleeding or perforation of the patient is prohibited; pregnant women and lactating women are prohibited. 2. Acetaminophen is used for cold and fever, arthralgia, neuralgia and migraine, cancer pain and post-operative pain relief. It is also used in patients who are allergic to, intolerant of, or unfit for aspirin. Adverse reactions are atopic dermatitis, granulocyte deficiency, thrombocytopenia, methemoglobinemia, anemia and hepatic and renal impairment in a few cases. Contraindications are prohibited for those who are allergic to the product; caution should be exercised in cases of hepatic and renal insufficiency; caution should be exercised in pregnant and lactating women. The drug should be taken under the guidance of a physician.