Inflammation in the bottom layer of the skin may be due to contact dermatitis, bacterial infection, insect bite dermatitis, etc. You can apply topical medications such as hormonal drugs, anti-infective drugs, etc., or oral antihistamine and anti-infective drugs to treat the problem, and pay attention to your diet and skin care in general. 1. It may be due to the use of irritating skin care products, cosmetics, resulting in local skin mucosal barrier damage. Can be applied locally hormonal drugs r such as mometasone furoate cream, halometasone and other medications, serious oral antihistamine drugs such as loratadine and other drugs. 2. Local bacterial infection can be applied locally mupirocin soft and other treatments, oral clindamycin and other drugs if necessary. 3. In summer or mosquito season more should use mosquito nets, avoid to mosquitoes more places, the emergence of erythema papules, can be applied locally Benadryl cream and other drugs treatment. Appearance of inflammation in the bottom layer of the skin timely consultation, the above drugs should be under the guidance of a doctor for treatment.