Neonatal hemolysis may occur if the newborn is AB and the mother has type A, B or O blood; neonatal hemolysis does not occur if the mother is AB. The presence of A and B antigens on the surface of the erythrocyte membrane in newborns with AB blood type, and the presence of anti-B antibodies in the plasma of mothers with blood type A, anti-A antibodies in the plasma of mothers with blood type B, and anti-A and anti-B antibodies in the plasma of mothers with blood type O may result in an antigen-antibody reaction leading to hemolysis of the newborn, while hemolysis will not occur if the mother with blood type AB does not have anti-A and anti-B antibodies in her plasma. Hemolysis of the newborn does not occur if the mother has AB blood type, regardless of the blood type of the newborn. This is because the absence of anti-A and anti-B antibodies in the mother’s plasma will not bind to antigens on the red blood cell membranes in the newborn’s blood. In addition to ABO hemolysis, there may also be Rh hemolysis. It is recommended to consult the Obstetrics and Gynecology Department and the Neonatology Department for complete determination of ABO and Rh blood groups, so that the risk of neonatal hemolysis can be evaluated by specialists, and preventive or therapeutic treatment can be carried out under the guidance of physicians.