CT-guided thoracolumbar sympathetic nerve block can treat hyperhidrosis of the hands and feet. The cause of hyperhidrosis is unknown, but it may be caused by the dysfunction of the sympathetic nerves innervating the hands and feet. Under normal circumstances, the sympathetic and parasympathetic nerves work together to regulate the body’s physiological activities. In patients with hyperhidrosis, the sympathetic nerves innervating the hands and feet are hyperfunctional, leading to vasoconstriction of the hands and feet, profuse sweating of the palms, and a cold, clammy state due to vasoconstriction of the skin. CT-guided thoracolumbar sympathetic nerve block is a minimally invasive technique that blocks the sympathetic nerves innervating the hands and feet under local anesthesia to treat hyperhidrosis. The success rate of sympathetic nerve block for hyperhidrosis is very high and there is usually no scarring, with most patients being discharged from the hospital after 1 week of treatment. It is recommended to go to a regular hospital for treatment of excessive sweating of the hands and feet under the guidance of a doctor.