Human leukocyte antigen b27 is positive, relatively unserious, and can be controlled with aggressive treatment after the cause is clarified. Human leukocyte antigen b27, or HLA-B27, is a marker antibody for rheumatoid arthritis, which helps to diagnose early rheumatoid arthritis and ankylosing spondylitis with high specificity. In about 90% of patients with ankylosing spondylitis, it can be positive. Early rheumatoid arthritis and ankylosing spondylitis can be relieved and is usually not serious with aggressive anti-inflammatory and analgesic (non-steroidal anti-inflammatory drugs, such as ibuprofen), anti-rheumatic (leflunomide, methotrexate), and symptomatic treatment. Few normal people, can also appear human leukocyte antigen b27 positive, need to pay attention to the identification, it is recommended to consult a doctor, under the guidance of a professional doctor, standardized treatment. Drugs should be used in accordance with medical advice.