There is no quick cure for a runny nose in a cold, but it can be relieved by topical nasal drops and oral medications. The symptom of runny nose in colds is due to acute rhinitis caused by viral infection, and various inflammatory mediators lead to congestion and edema of the nasal mucosa, and increased secretion of the glands, resulting in the symptom of runny nose. If the symptoms are mild, general treatment can be given, such as drinking more water, pay attention to rest. If the symptoms are severe, nasal decongestants such as hydroxymetazoline hydrochloride drops and ephedrine drops can be used to shrink the nasal mucosa, and chlorpheniramine and compound aminophenolamine can be given to relieve nasal congestion and runny nose caused by cold. If there is a basis for bacterial infection such as runny nose, penicillins such as amoxicillin and cephalosporins such as cefixime can be given. Runny nose can also be caused by other diseases, such as allergic rhinitis. If the symptoms do not improve or worsen, it is recommended to consult a doctor in time, under the guidance of the doctor’s medication, so as not to delay the condition.