The clinical significance of a low white blood cell count is that it suggests that pathologic factors such as immunocompromise, infections, and hematologic disorders may be present. 1. If there is a bacterial infection, neutrophils will proliferate to fight the bacteria, which is an essential part of the immune system. If the white blood cell count is low, the most direct result is that the patient’s immunity will be lowered, and the risk of infectious diseases such as influenza will be increased. 2. Low white blood cell counts can also be seen in hematologic disorders, such as severe aplastic anemia leading to low white blood cell counts, or multiple myeloma leading to hematopoietic dysfunction and premature apoptosis of white blood cells. There may also be other causes of low white blood cell count, such as systemic lupus erythematosus, liver disease, etc. If the white blood cell count is low, further examination should be carried out to clarify the diagnosis, and specific treatment should be received under the guidance of physicians.