Thrombocytopenia in myelodysplastic syndromes is due to ineffective hematopoiesis. Myelodysplastic syndromes are characterized by pathological hematopoiesis of the blood cells, and patients experience anemia, infections, and bleeding, often with dizziness, purple lips, pallor, and weakness, and patients with infections have fever, and bleeding due to low platelets that can lead to skin purpura, and female patients tend to have excessive menstrual flow during menstruation. Most patients have neutropenia. Neutrophils are infection-fighting cells, and with neutropenia the body becomes more susceptible to infections, often with symptoms such as fever. It is important to note that myelodysplastic syndromes are malignant hematopoietic disorders with a high risk of transformation to acute leukemia.