Middle-aged women chest congestion may be cardiovascular system diseases, respiratory system diseases and other disease factors caused, may also be in a long-term hypoxic environment, adverse drug reactions and other non-disease factors caused. 1. Disease factors: (1) circulatory system diseases: for example, coronary heart disease, patients will appear chest congestion symptoms, and myocardial ischemia caused by low blood oxygen content of blood type. (2) Respiratory system diseases: for example, bronchial asthma, patients will have symptoms of chest congestion due to ventilation dysfunction. (2) Non-disease factors: levofloxacin and valsartan can have the adverse reaction of chest tightness and congestion after taking them. Prolonged exposure to insufficient oxygen, emotional excitement, low-pressure environments can also cause symptoms of chest tightness and congestion. Middle-aged women with symptoms of chest tightness and congestion may also have other causes, and it is recommended to go to the hospital in time for timely treatment.