Quadruple therapy has been taken for two days usually does not develop drug resistance. 1. Quadruple therapy consists of proton pump inhibitors (such as omeprazole, etc.), clarithromycin, metronidazole or amoxicillin, bismuth (colloidal bismuth pectin, etc.), etc., it is the first line of the first choice for the eradication of Helicobacter pylori, and resistance is very easy to occur to a single medication, so it is necessary to use a variety of drugs in combination, so the quadruple therapy is taken for two days, and generally will not appear drug-resistant. 2. The medication course of quadruple therapy is generally 14 days, can effectively eradicate H. pylori, strictly in accordance with the doctor’s requirements of the dose of standardized treatment, not to stop the drug, otherwise it will affect the therapeutic effect, one month after the end of the treatment, and then go to the hospital to recheck whether H. pylori has been eradicated. 3. It should be noted that pregnant and breastfeeding women are prohibited from using quadruple therapy, alcohol is prohibited during the medication, and the diet should be light and easy to digest, and eat less cold, greasy, spicy and stimulating food.