In case of advanced esophageal cancer that cannot eat, patients need to follow medical advice for surgical treatment, radiotherapy, chemotherapy and so on. 1. Surgical treatment: Usually, patients with advanced esophageal cancer need to evaluate kidney function, heart function and nutritional status before surgery and assess the risk of surgery. If conditions permit, open thoracic surgery or thoracolaparoscopic surgery should be performed under the guidance of doctors. 2. Radiotherapy: usually radiotherapy for esophageal cancer can be divided into preoperative radiotherapy, postoperative radiotherapy and radical radiotherapy. Generally speaking, preoperative radiotherapy can increase the surgical resection rate and improve long-term survival, while some patients with incomplete resection during operation can undergo postoperative radiotherapy to further remove the residual cancerous tissues. If the patients cannot be operated, radical radiotherapy can be considered. 3. Chemotherapy: Usually, for patients with good physical conditions and no relevant contraindications, patients should follow the doctor’s instruction to use chemotherapy drugs such as cisplatin, 5-fluorouracil, irinotecan, paclitaxel and so on. It is suggested that when patients with advanced esophageal cancer are unable to eat, they should actively cooperate with doctors to carry out systematic treatment, so as to prolong the survival time. Please strictly follow the doctor’s prescription for drug treatment and do not use drugs on your own.