Punctate myelin dysplasia will mainly show symptoms of intellectual abnormality, physical abnormality and facial abnormality. Punctate myelin dysplasia has more symptoms, so it should be examined when there is discomfort, and be detected and treated as early as possible, so as to avoid causing adverse effects. 1. intellectual abnormality: patients with punctate myelin dysplasia will show developmental delay, slow reaction, mental retardation. 2. physical abnormality: patients with punctate myelin dysplasia will also show developmental delay, slow reaction, mental retardation. 2. Physical abnormality: there will be muscle weakness, incomplete development of bones and joints or even developmental regression, limited movement, progressive spasticity, tremor and ataxia. 3. Facial anomalies: the patient may also present with medial canthus, ptosis, mid-face dysplasia, as well as visual neurological disorders such as cataracts, trembling of the eyes, and retinitis pigmentosa. Myelin dysplasia is due to brain dysplasia, resulting in brain nerve information transmission and analysis of the obstacle, the clinical manifestations are more, when there is discomfort should be timely to the hospital for examination and diagnosis, as soon as possible to clarify the cause of the disease in the guidance of a professional doctor to carry out targeted treatment, to avoid delaying the condition aggravation of the symptoms caused by the adverse effects.