There is no such thing as “the most effective” treatment for the disease, and the treatment should be based on evidence, with commonly used remedies including Yu Ping Feng San, Gui Spleen Tang, and Angelica Six Yellow Tang. Hand sweating belongs to the category of “spontaneous sweating” and “night sweating” in Chinese medicine, which is mostly due to post-disease weakness, insufficient endowment (inborn constitution and poor functioning), and emotional disorders, etc., and needs to be diagnosed and treated according to the evidence. 1. Lung Wei is not solid: the patient’s symptoms are tiredness and fatigue, body aches and pains, white moss, thin and weak pulse, the treatment is to benefit the qi and solidify the surface, which can be used to use Jade Screen Fung San. 2. Insufficiency of heart and blood: patients with palpitations (rapid heartbeat, often accompanied by panic), insomnia, lack of honor, pale tongue and thin pulse, treatment is to nourish the heart and replenish the blood, and can use the spleen soup. 3. Yin deficiency and fire exuberance: the patient’s symptoms include heart heat (heat in the heart of the hands and feet, and self-consciousness of the heart and chest), flushing of the cheekbones (redness of the zygomatic bone area on both sides of the face), thirst, red tongue with little moss, and a fine pulse (the pulse becomes narrower and finer, and the rate is accelerated). The treatment method is based on nourishing Yin and lowering the fire (nourishing the Yin essence and lowering the fire), and the patient can use Angelica Six Horns Soup. The above prescription should be used by a TCM doctor after diagnosis, avoid self-medication to avoid adverse consequences.