The common causes of fever in the middle of the night in children include respiratory tract infections, digestive system diseases and autoimmune diseases. 1. Respiratory tract infections: for example, acute herpes pharyngitis, acute tonsillitis, common cold and so on. Mostly due to low indoor temperature, stirring the quilt cold, resulting in bacteria, viruses and other pathogens invade the body. All can lead to children in the middle of the night to varying degrees of fever symptoms, and there will be a headache, fatigue and other systemic symptoms. 2. Digestive system diseases: such as acute gastroenteritis, bacterial dysentery, acute appendicitis, etc., will make the body white blood cell count increase, when the symptoms are serious, it will also lead to the child in the middle of the night fever, and the child will sometimes severe abdominal pain. 3. Autoimmune diseases: such as rheumatic fever, Kawasaki disease, juvenile idiopathic arthritis and other diseases, will destroy the body’s immunity, which will lead to the child in the middle of the night fever phenomenon of varying degrees. 4. Other: If a child is vaccinated during the day, an adverse reaction can occur at night while sleeping, leading to a fever in the middle of the night, usually a low fever, which can subside on its own. As you can see, there are many reasons for children to have a fever in the middle of the night, if the fever is particularly serious, it is recommended to go to the hospital in a timely manner, according to the cause of the symptomatic treatment.