Low ApoA1 should not be remedied blindly, and it is necessary to improve the relevant examinations to clarify the cause of the disease and provide targeted treatment. Normally, low ApoA1 is seen in familial ApoA1 deficiency, familial A-lipoprotein deficiency and familial low HDL anemia. Patients with acute myocardial infarction, diabetes mellitus, chronic liver disease, nephrotic syndrome and cerebrovascular disease may also have low ApoA1. Therefore, further examination is needed to find out the cause of the disease, followed by targeted treatment. For example, if low ApoA1 is induced by diabetes mellitus, it is necessary to control blood glucose in time, pay attention to the diet, avoid excessive intake of high oil and high-fat foods, and eat more fresh vegetables, and strengthen the exercise, and the ApoA1 can be restored to the normal level. If the disease is caused by familial diseases, it is necessary to adhere to the basis of nutritional treatment, but also need to avoid drinking alcohol, oral estrogen, diuretics and other drugs. Low ApoA1 should be treated according to the doctor’s instructions, and should not be treated blindly by oneself.