Redness and peeling of the skin next to the mouth need to be treated according to the specific cause, which may be related to contact dermatitis, xerostomia, perioral eczema, etc., and general treatment and medication should be taken after a clear diagnosis. 1. Contact dermatitis: Mouth contact with allergic substances, such as food, cosmetics, lipstick, etc., may cause an allergic reaction in the mouth, resulting in redness and peeling of the skin next to the mouth. Patients should avoid contact with allergens and take anti-allergy drugs such as cetirizine and loratadine as prescribed by the doctor. 2. Keratitis: Keratitis mainly occurs in the corner of the mouth area, may be related to malnutrition, trauma, infection and other factors. Patients can use mupirocin ointment and erythromycin ointment to apply, and at the same time, pay attention to diet, avoid spicy and stimulating food. In addition, it is necessary to do a good job of local hygiene. 3. Perioral eczema: eczema around the mouth can also lead to peeling, redness, swelling, blisters, vesicles and other phenomena, you can use anti-allergic drugs, such as loratadine, cetirizine, etc., and at the same time, you can cooperate with the Dinocaprolactone cream to be coated. In addition, patients need to keep the local dry hygiene, keep a light diet. There are many reasons for the redness and peeling of the skin next to the mouth, it is recommended that patients go to the hospital in time to take a systematic examination, a clear diagnosis to give targeted treatment, the above drugs should be used under the guidance of a doctor, not to be used indiscriminately, so as not to lead to adverse consequences.