seeg radiofrequency thermocoagulation, or stereotactic EEG-guided radiofrequency thermocoagulation, can better localize epileptic foci and has a better therapeutic effect. Epilepsy is a syndrome caused by abnormal synchronous discharges of neurons in the brain. For drug-refractory epilepsy, surgery can achieve better results. Stereotactic EEG-guided radiofrequency thermocoagulation combines anatomical, electrical, and clinical features to better localize epileptogenic foci. There are three main mechanisms of stereotactic EEG-guided radiofrequency thermo-coagulation. First, thermo-coagulation may destroy neurons and eliminate abnormal discharges, second, thermo-coagulation may destroy nerve fibers and cut off the conduction of discharges, and third, thermo-coagulation may change the structure of the brain, which may in turn affect the abnormal function of the brain. Stereotactic EEG-guided radiofrequency thermocoagulation is a safe and reliable surgical method that can be used in the routine treatment of refractory epilepsy with good therapeutic effects. Patients should choose the appropriate treatment under the guidance of their doctors.