Leukemia m4eO is medically known as M4EO. Many patients with leukemia M4EO can be cured by chemotherapy, and severe cases can be treated with allogeneic hematopoietic stem cell transplantation. In the new WHO leukemia typing, M4EO belongs to a type with a good prognosis, and M4EO type of leukemia can be cured by chemotherapy to achieve a high cure rate, and the drugs include cytarabine, Zoerythromycin and so on. However, whether leukemia M4EO can be cured after chemotherapy should be judged according to the patient’s comprehensive condition, physical fitness, and treatment plan. Early adequate systemic treatment and patients who are young, in good condition, and do not have underlying diseases can be cured after treatment. However, for high-risk patients, allogeneic hematopoietic stem cell transplantation is usually required after induction of remission for fundamental treatment. The efficacy of the same disease is different if the patient’s physical condition, stage of the disease, and treatment method are different, and standardized treatment should be carried out under the guidance of doctors.