CA125 single high should actively identify the cause of the disease, and choose drug or surgical treatment after clarifying the cause of the disease. There are many reasons for CA125 elevation, there are benign diseases such as pelvic inflammatory disease, ovarian cysts, etc. can lead to CA125 elevation, usually after the use of drug treatment, CA125 gradually return to normal. Pelvic inflammatory disease can have lower abdominal pain, fever, increased vaginal discharge and other manifestations, to anti-infection treatment, such as metronidazole, penicillin, etc., and if necessary, surgical removal of inflammatory lesions. Most of the ovarian cysts do not need to be treated and are followed up for observation. If rupture of the cyst occurs or torsion of the tip occurs, surgical stripping of the cyst is required. However, when CA125 is obviously elevated or persistently elevated for many times, malignant tumor should be highly suspected, especially gynecological tumors, such as ovarian cancer, and some lung cancers can also have elevated CA125. Once malignant tumor is diagnosed, it should be consulted immediately and treated according to the stage. Early-stage ovarian cancer and early-stage lung cancer can be treated by surgical resection supplemented by radiotherapy, while advanced tumors can be treated by radiotherapy or palliative treatment. Patients with high CA125 should complete relevant examinations under professional doctor’s guidance, such as chest CT, gynecological examination, abdominal ultrasound, etc. to find out the cause of the disease, and then treat the disease according to the cause of the disease, and the patients should not take medicines on their own in order to avoid adverse consequences.