E6E7 negativity indicates a relatively low chance of entering high-grade cervical lesions.
E6E7 refers to two gene regions in the human papillomavirus (HPV) genome. The human papillomavirus (HPV) genome consists of two types of coding gene regions, the first being the two late-phase regions (L1 and L2) and the second type of seven early-phase regions (E1, E2, E4, E5, E6, E7, and E8) genes.
Clinically, E6E7 results indicate that the presence or absence of the protein encoded by the corresponding gene predicts the chance of cervical epithelial carcinogenesis. The main mechanism is that activation of these two proteins inhibits the major oncogenic proteins, thus allowing unlimited proliferation and malignant transformation of the infected cells.
However, when E6E7 is positive, it does not signal the presence of cancer in the human body, but only means that there is a greater chance of high-grade cervical lesions. At this point, further examination, such as cervical cytology, histopathology, etc. to clarify whether there are cervical lesions.