Low-grade intraepithelial neoplasia of gastric sinus can be cured by active treatment, and it will not affect the natural life span, but if it continues to deteriorate to form gastric cancer, it may be life-threatening. Low-grade intraepithelial neoplasia of gastric sinus refers to mild or moderate atypical hyperplasia occurring in the mucosal epithelium of gastric sinus, which is a kind of precancerous lesion, but the degree of the lesion is relatively mild, and usually it has a chance to be cured through active treatment such as surgical resection, etc., and the cure will not affect the natural life expectancy. Low-grade intraepithelial neoplasia of gastric sinus has a very small chance of becoming cancerous, but if it is delayed for a long period of time without treatment, coupled with the influence of other factors such as poor dietary habits, it may lead to deterioration and cancerous transformation to form gastric cancer, which will pose a serious threat to the patient’s life, and in serious cases, may lead to death. It is recommended to go to the hospital in time for consultation and early and regular treatment.