Itchy palms with small bumps and peeling skin are considered to be caused by eczema, atopic dermatitis, herpes sweat and other diseases. 1. Eczema: related to chronic infection, heredity, autoimmune function and other internal and external factors, so that the patient has itchy skin on the palms of the hands, erythema, papules, blisters, flaking and other symptoms. 2. Atopic dermatitis: genetic factors, abnormal immune function, abnormal skin barrier function and other factors may induce atopic dermatitis, the patient’s skin is dry, itchy and may be flaky. 3. Sweat herpes: hand contact allergens, dermatophytosis infections and other reasons may trigger sweat herpes; secondly, if the long-term in a humid and hot environment, mental stress, may also be induced by sweat herpes, resulting in itchy pimples and peeling of the palms of the hands. There are various reasons for itchy palms with small bumps and peeling skin, and it is recommended that the patient go to the hospital for treatment to clarify the cause of the disease.